Harr Clinical Chemistry Practice Test 2025 – Complete Exam Prep

Hypochloremia, which refers to low levels of chloride in the blood, can particularly be expected in cases of metabolic alkalosis. In metabolic alkalosis, the body often compensates by losing chloride ions through renal mechanisms or gastrointestinal losses. This condition may arise from prolonged vomiting, excessive diuretic use, or certain hormonal imbalances, which all contribute to a decrease in chloride levels as the body retains bicarbonate to compensate for the alkalotic state.

While respiratory alkalosis can also be associated with shifts in electrolyte levels, it typically leads to hypokalemia and may not have a direct relationship with chloride levels. Metabolic acidosis can lead to hyperchloremic acidosis in some situations but does not generally present with hypochloremia. Thus, metabolic alkalosis is the condition most consistently associated with hypochloremia, aligning with the choice presented.